Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

Blog Article

Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 coats Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Department of Biological Systems Engineering, University of Wisconsin-Madison, Madison, WI, USAAbstract: The use of nanoparticles holds promise for medical applications, such as X-ray imaging, photothermal therapy and radiotherapy.However, the in vivo toxicity of inorganic nanoparticles raises some concern regarding undesirable side effects which prevent their further medical application.Ultrasmall sub-5.5 nm particles can pass through the barrier for renal clearance, minimizing their toxicity.

In this letter we address some recent interesting work regarding in vivo VEGETARIAN OMEGA 3 toxicity and renal clearance, and discuss the possible strategy of utilizing ultrasmall nanomaterials.We propose that small hydrodynamic sized nanoclusters can achieve both nontoxic and therapeutic clinical features.Keywords: in vivo clearance, gold nanoparticles, small size.